and Inflammatory Neuropathies


Dysimmune inflammatory neuropathies or immune-mediated peripheral neuropathies are a heterogenous group of disorders affecting the peripheral nervous system (PNS), due to dysregulation of the immune system. The course of the disease is varying and can be acute, sub-acute, chronic or relapsing-remitting. Such peripheral neuropathies are generally characterised by progressive muscle weakness and accompanied by sensory deficits and can be caused by immune response against autoantigens in the PNS. There are several types of immune-mediated neuropathies such as Guillain– Barre syndrome (GBS) and its subtypes, chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and paraproteinemic neuropathies. Given that the main pathophysiology is immunemediated, it would mean that with early detection, potential treatment of neuropathies is possible. This review aims to highlight the pathophysiological mechanisms, immunological processes and management of these conditions.